My second suggestion concerns gilds. These steps will ensure that you always get the maximum DPS at all times.
- Once you begin to pass Zone 200 without having to stop and farm, start re-gilding onto Treebeast, Ivan, Brittany, Samurai, and Seer. Use the "De-Gild" button for this.
- After Zone 500, put all your gilds onto Samurai. You can hit "Boost" a bunch of times, but on mobile pressing the double-arrows will just move all of them at once. (I believe Shift+Click is the PC equivalent.) Re-gild to him after every ascension. (The heroes in the previous step will not be regilded until after a transcension.)
- Keep a bank of hero souls so that you can re-gild during a run. Since you will re-gild to Samurai after each ascension, this is the only way to carry out the following steps.
- When Samurai hits level 2500, re-gild to Atlas. When Atlas hits level 1500, re-gild to Terra. Continue moving up to the next hero each time you hit level 1500. You will probably ascend and transcend several times during this process; for the former, you will go back to Samurai and work your way up; for the latter, you will start back at the first step.
- Eventually you'll hit Wepwawet, currently the final hero. When Wepwawet gets his upgrade for Betty, switch to her. When Betty is around the mid-9000's in level, you should be able to get Wepwawet's upgrade for Midas. Get that, and then switch to Midas. When Midas gets to about level 13,000, Wepwawet will be the more efficient hero once again; switch back to Wepwawet.
Speaking of transcension, always respec when you transcend. Unlike when you respec ancients, respeccing your outsiders is completely free. It is sometimes advantageous to lower one outsider's level in favor of another, and for the calculator's purposes this also lets you see how many ancient souls you have at the beginning of your run. The outsiders make your ancients better. In some cases this is direct, like Ponyboy boosting Solomon, or Xiliqil boosting Siyalatas and Libertas; in other cases, less so. Chor'goloth makes ancients cheaper, while Phandoryss and Borb respectively raise your transcendent power (TP) and increase your TP reward. Basically, you're getting more souls that can be spent on more ancient levels. The calculator will help you find the perfect balance to maximize this.
This brings me to Morgulis. I said earlier to ignore what the calculator says about him; this is because Morgulis' level is easy to calculate in your head. In an idle build, he should be your last ancient; in a hybrid build, he's your last one before getting the active ancients. Either way, he's not a huge priority. So what is Morgulis? He's a bank. Yes, the description says he makes hero souls more powerful, but this is incorrect: all Morgulis does is add a flat +11% additive bonus to your DPS per level. In other words, one Morgulis level is exactly 1% better than having one hero soul in reserve.
Since Morgulis is just a better soul bank, you should just put all your spare souls into him after leveling up the other ancients. Now, you will need to keep some souls in reserve for re-gilding, but if you've been paying attention to your spending habits then you know about how many you need to keep. (Personally, I just keep giving him "MAX" souls until I'm about two MAXes away from zero.) You might be thinking, "Shouldn't I be saving some of these hero souls to buy ancients later?" No. If you're following the calculator, the number of hero souls you gain should be at least doubling with each ascension. Besides, by the time you start dumping souls into Morgulis like this, the cost to purchase and level up other ancients will be peanuts compared to the amount of souls you're raking in. Besides, the extra DPS from Morgulis will let you do slightly deeper runs anyway.
One last thing: Morgulis is affected by Chor, but this will only show up when purchasing multiple levels; basically, some of his levels will be completely free when buying in bulk. This is why I always level him up with "MAX." You get tons of free levels this way; and since the number of levels bought with "MAX" increases every time you hit a new order of magnitude, Morgulis will get progressively more levels for free.
That's really all there is to say about succeeding in Clicker Heroes. Hopefully exploiting these little tricks and reaching record-high zones will tide you over until Playsaurus releases Clicker Heroes 2 (which promises to be a far more interesting game).